horseshoe bats – Communicable Diseases Research

SARS-like Coronaviruses in Horseshoe Bats ( Rhinolophus spp.) in Russia, 2020

Article

Published on 2022-01-092022-10-28
Journal: Viruses
[Category] COVID-19, SARS,

Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections

비교 게놈 분석은 코로나 바이러스 감염에 대한 다양한 수준의 포유류 적응을 보여줍니다.

Comparative Study

Published on 2021-11-182022-09-10
Journal: PLoS Computational Biology
[Category] MERS, SARS, 바이오마커, 유전자 메커니즘,

[키워드] 229E ACE2 ACE2 protein ACE2 proteins acting adaptation adaptive Affect Amino acid amino acid substitution amino acid substitutions aminopeptidase aminopeptidase N analysis angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Animal host APN bats binding causative agent cause caused cellular receptor Chinese Chinese Horseshoe bats clade class common cold Comparative coronavirus coronavirus Coronavirus infection Coronaviruses COVID-19 Evidence evidence of Evolution genomic Genomic analysis HCoV HCoV-229E Health horseshoe horseshoe bats Host host receptor host susceptibility hosts Human coronavirus human coronavirus 229E Interaction Lineage lineages mammal mammalian pathogen Pathogens pattern Phylogeny primates Protein receptor Research reservoir resistance to infection resistance to infections respiratory Respiratory Coronavirus reveal rodent rodents SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein SARS-like coronaviruses SARS-like virus SARS-like viruses severe acute respiratory coronavirus severe acute respiratory coronavirus 2 severity of symptom shown species Spike protein susceptible symptomatic disease the SARS-CoV-2 these viruses Tolerance Variation Viral viral entry viral infection viral infections Viral vector virus virus viruses zoonotic origin
[DOI] 10.1371/journal.pcbi.1009560 PMC 바로가기 [Article Type] Comparative Study

Interspecies Jumping of Bat Coronaviruses

박쥐 코로나 바이러스의 산간 점프

Review

Published on 2021-10-292022-09-10
Journal: Viruses
[Category] MERS, SARS, 치료기술,

[키워드] bat bats caused chance China Chinese Horseshoe bats coronavirus CoV COVID-19 CoVs disease disease outbreaks Epidemic epidemics/pandemics event events experiments fatality Genome genome organization genomic studies genomic study horseshoe horseshoe bats Human interspecies jumping Jumping measure MERS MERS-CoV MONITOR Mortality occurred outbreak pandemic Pandemics Patient Phylogenetic Pipistrellus Pneumonia PROTECT public health recombineering reduce reported reservoir SADS SARS SARS epidemic SARS-CoV SARS-CoV-2 SARS-related CoV Spread Threats Transmission Tylonycteris virus Wuhan Wuhan, China
[DOI] 10.3390/v13112188 PMC 바로가기 [Article Type] Review

SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for spillback to New World rodents

사슴 쥐 사이의 SARS-CoV-2 감염, 신경병증 및 전파: 신세계 설치류로의 유출에 대한 의미

Research Article

Published on 2021-05-192022-09-10
Journal: PLoS Pathogens
[Category] 진단, 치료기술,

[키워드] Amino acid amino acids animal model Asia bat BEI Resource BEI Resources blood-brain barrier Brain CD4 China coronavirus coronavirus disease Coronavirus disease-19 COVID-19 COVID-19 disease COVID-19 patients CXCL10 detectable disease elevated event Evidence expression fixation horseshoe bats Host humans IFNα IFNβ IFNγ IL-21 immune response in vivo Infection infiltration infiltration of neutrophil infiltration of neutrophils Inflammation inflammatory immune response innate immune response insert insertion intermediate host intestines Localization lung Lungs macrophages mice Mutation N-terminal domain neurological manifestation neurological manifestations Neuropathogenesis Neutrophils New World North America OAS2 occur occurred olfactory olfactory bulb oral swab oral swabs other coronaviruses pandemic passages pathology pathway Peromyscus maniculatus persistence Population predicted preponderance Pycard reservoir hosts respiratory Respiratory disease respiratory tract robust rodent SARS-CoV-2 SARS-COV-2 infection Spike protein susceptible sustained Taste TBK1 TBX21 the spike protein tongue Transmission type I upper respiratory tract Viral Viral RNA virus virus entry virus replication
[DOI] 10.1371/journal.ppat.1009585 PMC 바로가기 [Article Type] Research Article

Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2

편자박쥐 ACE2 orthologs에서 파생된 돌연변이는 SARS-CoV-2의 ACE2-Fc 중화를 향상시킵니다

Research Article

Published on 2021-04-092022-09-10
Journal: PLoS Pathogens
[Category] MERS, SARS, 변종,

[키워드] ACE2 ACE2 binding ACE2 ortholog ACE2 orthologs ACE2 proteins ACE2 residue ACE2-Fc acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 bat bat ACE2 bats binding binding affinity both viruses Cell cellular receptor Combination Consensus coronavirus described domain ENhance expressing FIVE hACE2 heterogeneity horseshoe bat horseshoe bats Human human ACE2 Hypothesis identify impacted inactive infect Infection Infectious virus Interaction intermediate introduced investigated Mutation neutralization neutralize neutralized Neutralizing ortholog orthologs pangolin pangolins potency Protein pseudovirus pseudoviruses RaTG13 RBD RBDs receptor receptor ACE2 Receptor-binding domain Region regions residue respiratory S-protein SARS-CoV SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus SARS-CoV-2 pseudoviruses SARS-CoV-2 RBD SARS-like coronavirus SARS-like coronavirus SARS-like viruses selection pressure severe acute respiratory syndrome Coronavirus soluble ACE2 species susceptibility the binding affinity the RBD the SARS-CoV-2 These data Variability variant Viral viral spike virus wild-type
[DOI] 10.1371/journal.ppat.1009501 PMC 바로가기 [Article Type] Research Article

Natural selection in the evolution of SARS-CoV-2 in bats created a generalist virus and highly capable human pathogen

박쥐에서 SARS-CoV-2의 진화에서 자연 선택은 일반 바이러스와 고도로 유능한 인간 병원체를 만들었습니다

Research Article

Published on 2021-03-122022-08-13
Journal: PLoS Biology
[Category] Biology and Life Sciences, Fulltext, SARS, 유전자 메커니즘, 조류인플루엔자, 치료기술,

[키워드] accompanied acting acute respiratory syndrome coronavirus adaptive Analysis ancestor Anti-viral Antiviral base bat bat Sarbecovirus bats can not Cell Coinfection coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 CpG CpG composition detect early phase Evidence evidence of Evolution Evolution of SARS-CoV-2 horseshoe bats Host hosts Human human pathogen humans include involved Lineage lineages mechanism moderate natural natural selection nucleotide nucleotides pandemic positive Positive selection progenitor recombinant Recombination required respiratory reveal RmYN02 Sarbecoviruses SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Support the cells the early SARS-CoV-2 Transmission virus viruses while
[DOI] 10.1371/journal.pbio.3001115 PMC 바로가기 [Article Type] Research Article